- Title
- Comparison of two doses of elemental iron in the treatment of latent iron deficiency: efficacy, side effects and blinding capabilities
- Creator
- Leonard, Alecia J.; Chalmers, Kerry A.; Collins, Clare E.; Patterson, Amanda J.
- Relation
- Nutrients Vol. 6, Issue 4, p. 1394-1405
- Publisher Link
- http://dx.doi.org/10.3390/nu6041394
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2014
- Description
- Adherence to iron supplementation can be compromised due to side effects, and these limit blinding in studies of iron deficiency. No studies have reported an efficacious iron dose that allows participants to remain blinded. This pilot study aimed to determine a ferrous sulfate dose that improves iron stores, while minimising side effects and enabling blinding. A double-blinded RCT was conducted in 32 women (18–35 years): 24 with latent iron deficiency (serum ferritin < 20 µg/L) and 8 iron sufficient controls. Participants with latent iron deficiency were randomised to 60 mg or 80 mg elemental iron or to placebo, for 16 weeks. The iron sufficient control group took placebo. Treatment groups (60 mg n = 7 and 80 mg n = 6) had significantly higher ferritin change scores than placebo groups (iron deficient n = 5 and iron sufficient n = 6), F(1, 23) = 8.46, p ≤ 0.01. Of the 24 who completed the trial, 10 participants (77%) on iron reported side effects, compared with 5 (45%) on placebo, but there were no differences in side effects (p = 0.29), or compliance (p = 0.60) between iron groups. Nine (69%) participants on iron, and 11 (56%) on placebo correctly guessed their treatment allocation. Both iron doses were equally effective in normalising ferritin levels. Although reported side-effects were similar for both groups, a majority of participants correctly guessed their treatment group.
- Subject
- ferrous sulfate; side effects; women; serum ferritin
- Identifier
- http://hdl.handle.net/1959.13/1045632
- Identifier
- uon:14491
- Identifier
- ISSN:2072-6643
- Rights
- © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
- Language
- eng
- Full Text
- Reviewed
- Hits: 6316
- Visitors: 3002
- Downloads: 420
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 208 KB | Adobe Acrobat PDF | View Details Download |